Sarcoidosis is a systemic, granulomatous disease that can manifest in multiple organs 1. Neurosarcoidose en paraneurosarcoidose ild care foundation. Diagnostic value of serumsoluble interleukin 2 receptor levels vs. Sarcoidosis patients in the active phase of the disease were significantly higher ykl40, sil2r, hscrp levels and ace activity than those in the.
The soluble interleukin2 receptor sil2r is used as a biomarker for disease severity in. All igg4rd patients had elevated serum sil2r levels compared to the reference value. The clinical value of serum soluble interleukin2 receptor. Our data suggest a role for serum sil2r as marker of pulmonary disease activity and ed in patients with sarcoidosis. Discrepant elevation of sil2r levels in sarcoidosis. Blood marker a sensitive tool to diagnose sarcoidosis. Pdf serum soluble interleukin2 receptor measurement in patients. Several biomarkers are used to assess disease activity and monitor response to therapy, including soluble interleukin 2 receptor sil 2r and angiotensinconverting enzyme ace 2. Serum soluble interleukin2 receptor measurement in. Discrepant elevation of sil 2r levels in sarcoidosis patients with renal insufficiency to the editor.
Potential biomarkers for diagnosis of sarcoidosis using. Measuring the levels of the blood marker soluble interleukin 2 receptor sil 2r in patients with suspected sarcoidosis offers more sensitive diagnostic guidance than other commonly used markers, and allows physicians to identify patients with multiple organ involvement, according to a recent study. Abstract skin lesions in sarcoidosis are often the initial symptoms that. Pdf serological biomarkers of granuloma progression in. Learn more about the eu clinical trials register including the source of. The lung is the most common site of a confirmatory biopsy, because pulmonary involvement is very common and because bronchoscopy affords easy. The clinical value of serum soluble interleukin2 receptor in. Sensitivity and specificity of serum soluble interleukin2 receptor for. However, no studies have evaluated whether serum sil 2r measurement is of use in establishing the diagnosis of sarcoidosis in patients who are suspected of sarcoidosis among other diseases. A predictive tool for an effective use of 18ffdg pet in assessing activity of sarcoidosis. The diagnosis, differential diagnosis, and treatment of. Discrepant elevation of sil2r levels in sarcoidosis patients with.
Biological role of the soluble interleukin2 receptor in sarcoidosis. In this study, sil 2r level tended to be higher in the. Request pdf discrepant elevation of sil 2r levels in sarcoidosis patients with renal insufficiency extract sarcoidosis is a systemic, granulomatous disease that can manifest in multiple organs. Data from 72 patients showed that sil 2r was more sensitive than both ace and lysozyme in supporting a diagnosis of sarcoidosis 52. Background the soluble interleukin 2 receptor sil2r has been proposed as a marker of disease activity in patients with sarcoidosis. Ace activity and sil2r concentration measurements, because these two blood markers are often used in the assessment and the followup of sarcoidosis. Elevated serum levels of sil2r correlate with disease activity in rheumatoid arthritis and sarcoidosis, diseases in which enhanced tcell activity. Serum sil2r may have a role as a diagnostic and prognostic marker in pulmonary sarcoidosis. The cohorts did not differ with regard to either c. The soluble interleukin 2 receptor sil 2r has been proposed as a marker of disease activity in patients with sarcoidosis.
Second, we examined sil 2r as a prognostic factor for sarcoidosis, as reported previously 15,16. Research article soluble interleukin2 receptor repub, erasmus. Angiotensin converting enzyme ace and the soluble interleukin 2 receptor sil 2r, two commonly used biomarkers for sarcoidosis, are nonspecific and therefore unsuitable for confirming the diagnosis. Ykl40, soluble il2 receptor, angiotensin converting enzyme and. Several biomarkers are used to assess disease activity and monitor response to therapy, including soluble.
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